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KMID : 1094020200370010038
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Journal of Veterinary Clinics
2020 Volume.37 No. 1 p.38 ~ p.41
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Histopathologic Characteristics of Canine Desmoplastic Melanoma
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Chaudhary Preeti Kumari
Chae Yeon
Kim Soo-Chong
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Abstract
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An 11-year-old castrated male miniature Schnauzer, weighing 8 kg, presented with multiple masses on the humeri. Grossly, the masses were separated from the surrounding soft tissues. Desmoplastic melanoma is an uncommon tumor in dogs. Fine-needle aspiration cytology showed large spindle-shaped cells with a high nuclear-cytoplasmic ratio. Histopathology showed interlacing bundles of fibroblast-like cells, highly pleomorphic multinuclear cells, occasional atypical spindle cells separated by fibrocollagenous stroma, and lymphocyte aggregates admixed with abundant collagen. The tumors were diffusely positive for S100a, a strong marker for desmoplastic melanoma, and negative for desmin. Herein, we report the pathobiology of a rare, uncommon variant of melanoma in a dog.
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KEYWORD
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desmoplastic melanoma, dog, immunohistochemistry, pathology, S100a
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